# Reactome

**Canonical:** https://apis.io/providers/reactome/  
**Website:** https://reactome.org/  
**APIs profiled:** 23

Reactome is a free, open-source, curated, and peer-reviewed biological pathway database. It provides comprehensive pathway data covering human biology and orthologous reactions for over 14 non-human species including mouse, rat, yeast, and fruit fly. The platform exposes two primary REST APIs — the Content Service for querying pathway data, molecular interactions, species comparisons, and reaction network visualization, and the Analysis Service for pathway enrichment analysis of gene and protein identifier lists. Both APIs are freely accessible without authentication, fully documented with OpenAPI (Swagger), and cross-referenced with major biological databases including NCBI, Ensembl, UniProt, KEGG, ChEBI, PubMed, and Gene Ontology. Data is authored by expert biologist researchers and maintained by Reactome editorial staff.

## Kin Score — 25.9 / 100 (emerging)

Scored 2026-08-20 under rubric 0.12.0. Trend: flat (+0.0 from 25.9).

| Facet | Score |
|---|---|
| Discoverability | 74.1 |
| Contract Quality | 52.5 |
| Governance | 9.8 |
| Contract Governance | 9.8 |
| Operational Transparency | 5.3 |
| Developer Ergonomics | 21.4 |
| Commercial Clarity | 0.0 |
| Access Clarity | 0.0 |

Regulatory layer — **Health**: 13.8 (matched via tags).

## Agent readiness — 30.3 (agent-aware)

| Dimension | Value |
|---|---|
| Spec Presence | yes |
| Agentic Access | derived |
| Reversibility Documented | no |
| MCP Server | no |
| Auth Clarity | no |
| Idempotency | no |
| Error Semantics | verified |
| OpenAPI Examples | verified |
| Rate Limit Signal | no |
| Event Surface Described | no |
| Agent Skills | no |
| Well Known Catalog | no |
| Consent Identity | no |
| Agent Card | no |
| Dry Run Mode | no |

## Access

Unknown — onboarding: unknown, pricing: unknown, trial: no (confidence: low).

## APIs (23)

- **Reactome database API** — Database info queries
- **Reactome discover API** — Reactome Data: Search engines discovery schema
- **Reactome diseases API** — Reactome Data: Disease related queries
- **Reactome download API** — Methods to download different views of a result
- **Reactome entities API** — Reactome Data: PhysicalEntity queries
- **Reactome events API** — Reactome Data: Queries related to events
- **Reactome exporter API** — Reactome Data: Format Exporter
- **Reactome identifier API** — Queries for only one identifier
- **Reactome identifiers API** — Queries for multiple identifiers
- **Reactome import API** — Imports an external result
- **Reactome interactors API** — Molecule interactors
- **Reactome mapping API** — Identifiers mapping methods
- **Reactome orthology API** — Reactome Data: Orthology related queries
- **Reactome participants API** — Reactome Data: Queries related to participants
- **Reactome pathways API** — Reactome Data: Pathway related queries
- **Reactome person API** — Reactome Data: Person queries
- **Reactome query API** — Reactome Data: Common data retrieval
- **Reactome references API** — Reactome xRefs: ReferenceEntity queries
- **Reactome report API** — Retrieves report files in PDF format
- **Reactome schema API** — Reactome Data: Schema class queries
- **Reactome search API** — Reactome Search
- **Reactome species API** — Species comparison
- **Reactome token API** — Previous queries filter

## Agentic access (1)

- **Reactome Agentic Access** — 122 operations · 31 acting

## Security (1)

- **Reactome Domain Security** — TLSv1.3 · DMARC

## Tags

Biological Pathways, Bioinformatics, Life Sciences, Pathway Analysis, Gene Enrichment, Molecular Interactions, Systems Biology, Open Science

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Profiled by [API Evangelist](https://apievangelist.com) and published on [APIs.io](https://apis.io/providers/reactome/). Scores are computed from the provider's own public artifacts under a published rubric.