# PubChem

**Canonical:** https://apis.io/providers/pubchem/  
**Website:** https://pubchem.ncbi.nlm.nih.gov/  
**APIs profiled:** 7

PubChem is NCBI's open chemistry database containing information on more than 100 million chemical compounds. It provides REST and view APIs for searching chemical structures, retrieving molecular properties, bioactivity data, safety information, and drug information. PubChem integrates data from hundreds of data sources and is freely accessible without authentication for standard use.

## Kin Score — 45.1 / 100 (developing)

Scored 2026-08-20 under rubric 0.12.0. Trend: flat (+0.0 from 45.1).

| Facet | Score |
|---|---|
| Discoverability | 81.5 |
| Contract Quality | 58.7 |
| Governance | 9.8 |
| Contract Governance | 9.8 |
| Operational Transparency | 36.8 |
| Developer Ergonomics | 14.3 |
| Commercial Clarity | 63.2 |
| Access Clarity | 63.2 |

Regulatory layer — **Health**: 23.8 (matched via tags).

## Agent readiness — 31.6 (agent-aware)

| Dimension | Value |
|---|---|
| Spec Presence | yes |
| Agentic Access | derived |
| Reversibility Documented | na |
| MCP Server | no |
| Auth Clarity | no |
| Idempotency | na |
| Error Semantics | no |
| OpenAPI Examples | verified |
| Rate Limit Signal | documented |
| Event Surface Described | no |
| Agent Skills | no |
| Well Known Catalog | no |
| Consent Identity | no |
| Agent Card | no |
| Dry Run Mode | na |

## Access

Unknown — onboarding: unknown, pricing: unknown, trial: no (confidence: low).

## APIs (7)

- **PubChem PUG View API** — The PUG View API provides access to the full structured compound and substance pages as seen on the PubChem website, organized as hierarchical sections covering names, structure...
- **PubChem PUG SOAP API** — Legacy SOAP/XML web service interface for PubChem providing structure search, identity search, and chemical standardization capabilities. Supports submitting queries and retriev...
- **PubChem Structure Image Service** — Generates 2D and 3D structure images for chemical compounds by CID, SID, SMILES, or InChI. Returns PNG images at configurable sizes, suitable for embedding in applications and d...
- **PubChem Identifier Exchange Service** — Bulk identifier conversion service for translating between PubChem CIDs, SIDs, and external identifiers such as CAS Registry Numbers, ChEMBL IDs, ChEBI IDs, and other registry i...
- **PubChem Compounds API** — Operations on compound records
- **PubChem Structure Search API** — Chemical structure search operations
- **PubChem Utilities API** — Utility operations

## Agentic access (1)

- **Pubchem Agentic Access** — 12 operations

## Security (1)

- **Pubchem Domain Security** — TLSv1.3 · HSTS · DNSSEC · DMARC

## Plans (1)

- **Plans**

## Tags

Chemistry, Chemical Compounds, Drug Discovery, Bioassay, Life Sciences, NCBI, Bioinformatics

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Profiled by [API Evangelist](https://apievangelist.com) and published on [APIs.io](https://apis.io/providers/pubchem/). Scores are computed from the provider's own public artifacts under a published rubric.