# Profluent

**Canonical:** https://apis.io/providers/profluent-bio/  
**Website:** https://www.profluent.bio  
**APIs profiled:** 0

Profluent is a Berkeley, California AI biology company building frontier protein language models and using them to design functional proteins for therapeutics, gene editing, agriculture, and industrial enzymes. Founded by Ali Madani — previously architect of the ProGen large language model for proteins at Salesforce AI Research — Profluent pairs in-house foundation models with a wet lab to author novel proteins from scratch and validate them experimentally. The company's research has been published in Nature Biotechnology and Nature, and it is best known for OpenCRISPR-1, which it describes as the world's first AI-designed gene editor, released freely for research and commercial use. Profluent also publishes the ProGen3 family of protein generation models, ProseLM for structure-conditioned protein design, the E1 family of protein encoder models, Protein2PAM for CRISPR-Cas PAM specificity prediction, and the CRISPR-Cas Atlas dataset. Commercial partnerships include a multi-target collaboration with Eli Lilly worth up to $2.25 billion, and deals with Ensoma, Corteva, Integrated DNA Technologies, and the Rett Syndrome Research Trust. Profluent is backed by Spark Capital, Insight Partners, Air Street Capital, Altimeter, and Bezos Expeditions. The company does not publish a hosted developer REST API or commercial SDK; its surface area for external builders is the Profluent-AI GitHub organization (model weights and inference code), the Protein2PAM web tool, and partnership engagements.

## Kin Score — 11.5 / 100 (emerging)

Scored 2026-08-20 under rubric 0.12.0. Trend: flat (+0.0 from 11.5).

| Facet | Score |
|---|---|
| Discoverability | 50.0 |
| Contract Quality | 0.0 |
| Governance | 0.0 |
| Contract Governance | 0.0 |
| Operational Transparency | 2.6 |
| Developer Ergonomics | 9.5 |
| Commercial Clarity | 21.1 |
| Access Clarity | 21.1 |

## Agent readiness — 0.0 (human-only)

| Dimension | Value |
|---|---|
| Spec Presence | no |
| Agentic Access | no |
| Reversibility Documented | no |
| MCP Server | no |
| Auth Clarity | no |
| Idempotency | no |
| Error Semantics | no |
| OpenAPI Examples | no |
| Rate Limit Signal | no |
| Event Surface Described | no |
| Agent Skills | no |
| Well Known Catalog | no |
| Consent Identity | no |
| Agent Card | no |
| Dry Run Mode | no |

## Access

Unknown — onboarding: unknown, pricing: unknown, trial: no (confidence: low).

## Security (1)

- **Profluent Bio Domain Security** — TLSv1.3 · HSTS · DMARC

## Tags

Artificial Intelligence, Protein Design, Protein Language Models, Foundation Models, Generative Biology, Gene Editing, CRISPR, OpenCRISPR, ProGen, ProseLM, Bioinformatics, Therapeutics, Agriculture, Industrial Enzymes, Open Source Models

---

Profiled by [API Evangelist](https://apievangelist.com) and published on [APIs.io](https://apis.io/providers/profluent-bio/). Scores are computed from the provider's own public artifacts under a published rubric.