# Onepot

**Canonical:** https://apis.io/providers/onepot/  
**Website:** https://www.onepot.ai  
**APIs profiled:** 1

Onepot (onepot.ai) is a San Francisco-based startup building an AI-powered, fully automated custom synthesis platform for small-molecule drug discovery. It combines ultra-high-throughput lab automation in its POT-1 lab with an AI organic chemist ("Phil") and reaction foundation models to search, quote, and synthesize make-on-demand molecules end to end, aiming to replace slow, error-prone CRO workflows. Onepot exposes a developer API and a Python client (published on PyPI as "onepot") that lets teams run Tanimoto similarity and SMILES/SMARTS substructure search over the full onepot CORE compound space, perform retrosynthetic decomposition with building-block and price/risk filters, stream real-time results over server-sent events, and place synthesis orders programmatically from their own pipelines using an API key.

## Kin Score — 19.3 / 100 (emerging)

Scored 2026-08-20 under rubric 0.12.0. Trend: flat (+0.0 from 19.3).

| Facet | Score |
|---|---|
| Discoverability | 75.9 |
| Contract Quality | 0.0 |
| Governance | 0.0 |
| Contract Governance | 0.0 |
| Operational Transparency | 0.0 |
| Developer Ergonomics | 61.3 |
| Commercial Clarity | 0.0 |
| Access Clarity | 0.0 |

Regulatory layer — **Health**: 15.0 (matched via tags).

## Agent readiness — 9.6 (agent-aware)

| Dimension | Value |
|---|---|
| Spec Presence | no |
| Agentic Access | no |
| Reversibility Documented | no |
| MCP Server | no |
| Auth Clarity | yes |
| Idempotency | no |
| Error Semantics | no |
| OpenAPI Examples | no |
| Rate Limit Signal | no |
| Event Surface Described | no |
| Agent Skills | derived |
| Well Known Catalog | no |
| Consent Identity | no |
| Agent Card | no |
| Dry Run Mode | no |

## Access

Self-serve signup — onboarding: self-serve, pricing: unknown, trial: no (confidence: medium).

## APIs (1)

- **Onepot API** — Programmatic access to onepot CORE for make-on-demand molecule discovery and synthesis. Run similarity (Tanimoto) and substructure (SMILES/SMARTS) search, optional retrosyntheti...

## MCP servers (1)

- **Onepot MCP Server**

## Security (2)

- **Onepot Authentication** — apiKey · 1 scheme
- **Onepot Domain Security** — TLSv1.3 · HSTS

## Tags

Company, Chemistry, Cheminformatics, Drug Discovery, Small Molecule Synthesis, Contract Research Organization, Artificial Intelligence, Machine-Learning, Lab Automation, Life Sciences

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Profiled by [API Evangelist](https://apievangelist.com) and published on [APIs.io](https://apis.io/providers/onepot/). Scores are computed from the provider's own public artifacts under a published rubric.