# National Institutes of Health (NIH)

**Canonical:** https://apis.io/providers/nih/  
**Website:** https://www.nih.gov/  
**APIs profiled:** 15

The US National Institutes of Health (NIH) provides a suite of public REST APIs for biomedical research, including PubMed literature search via E-utilities, ClinicalTrials.gov clinical trial data, chemical compound data through PubChem, gene and genome databases via NCBI Datasets, BLAST sequence alignment, and NIH research funding data through RePORTER.

## Kin Score — 41.4 / 100 (developing)

Scored 2026-08-20 under rubric 0.12.0. Trend: flat (+0.0 from 41.4).

| Facet | Score |
|---|---|
| Discoverability | 74.1 |
| Contract Quality | 59.5 |
| Governance | 9.8 |
| Contract Governance | 9.8 |
| Operational Transparency | 21.1 |
| Developer Ergonomics | 23.8 |
| Commercial Clarity | 50.0 |
| Access Clarity | 50.0 |

Regulatory layer — **Health**: 21.3 (matched via tags).

## Agent readiness — 41.9 (agent-ready)

| Dimension | Value |
|---|---|
| Spec Presence | yes |
| Agentic Access | derived |
| Reversibility Documented | no |
| MCP Server | no |
| Auth Clarity | yes |
| Idempotency | no |
| Error Semantics | verified |
| OpenAPI Examples | verified |
| Rate Limit Signal | documented |
| Event Surface Described | no |
| Agent Skills | no |
| Well Known Catalog | no |
| Consent Identity | no |
| Agent Card | no |
| Dry Run Mode | no |

## Access

Free · Self-serve signup — onboarding: self-serve, pricing: free, trial: no (confidence: high).

## APIs (15)

- **NCBI E-utilities (Entrez Programming Utilities)** — The public API to the NCBI Entrez system providing programmatic access to all Entrez databases including PubMed, PMC, Gene, Nuccore, and Protein. Supports searching, fetching, l...
- **PubChem Power User Gateway (PUG REST)** — Suite of REST APIs providing programmatic access to PubChem chemical compound data, including chemical structure searches, compound properties, biological assay data, and chemic...
- **NIH RePORTER API** — REST API providing programmatic access to NIH-funded research project data including grants, contracts, publications, and patents. Enables search and retrieval of funding record...
- **NCBI BLAST URL API** — API enabling developers to submit BLAST (Basic Local Alignment Search Tool) sequence searches via HTTPS for processing at NCBI or cloud service providers, check job status, and ...
- **PubMed Central (PMC) OA API** — APIs for programmatic access to PubMed Central's Open Access content, including file validation, Open Access service, and an ID converter for translating between PMCID, PMID, Ma...
- **National Institutes of Health (NIH) BioSample API** — #### Options to download BioSample data. This BioSample service allows you to get BioSample data as a data report.
- **National Institutes of Health (NIH) Gene API** — #### Options to download gene data, including the associated sequence and metadata. These gene services allow you to get gene metadata as a data report or download gene, transcr...
- **National Institutes of Health (NIH) Genome API** — #### Options to download assembled genome data, including the associated sequence, annotation and metadata. These genome services allow you to get genome metadata as a data repo...
- **National Institutes of Health (NIH) Organelle API** — #### Options to download RefSeq organelle genome data, including the associated sequence and metadata. These organelle services allow you to get RefSeq organelle genome metadata...
- **National Institutes of Health (NIH) Prokaryote API** — #### Options to download prokaryote gene data, including the associated sequence and metadata. These gene services allow you to download gene and protein sequence, and metadata ...
- **National Institutes of Health (NIH) Stats API** — Data statistics
- **National Institutes of Health (NIH) Studies API** — Related to clinical trial studies
- **National Institutes of Health (NIH) Taxonomy API** — #### Options to download taxonomy data. These taxonomy services allow you to get taxonomy data as a data report or download taxonomy data as a taxonomy data package, for taxonom...
- **National Institutes of Health (NIH) Version API** — Version info
- **National Institutes of Health (NIH) Virus API** — #### Options to download virus genome data, including the associated sequence and metadata. These virus services allow you to get virus genome metadata as a data report or downl...

## Agentic access (1)

- **Nih Agentic Access** — 116 operations · 41 acting

## Security (2)

- **Nih Authentication** — apiKey · 2 schemes
- **Nih Domain Security** — TLSv1.3 · HSTS · DNSSEC · DMARC

## Plans (1)

- **Nih Plans Pricing**

## Tags

Biomedical, Research, PubMed, Clinical Trials, PubChem, Genomics, Health, Science, Government

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Profiled by [API Evangelist](https://apievangelist.com) and published on [APIs.io](https://apis.io/providers/nih/). Scores are computed from the provider's own public artifacts under a published rubric.