# HotSpot Therapeutics

**Canonical:** https://apis.io/providers/hotspot-therapeutics/  
**Website:** https://www.hotspotthera.com/  
**APIs profiled:** 0

HotSpot Therapeutics is a clinical-stage biopharmaceutical company headquartered in Boston, Massachusetts, pioneering allosteric drug discovery by targeting "natural hotspots" — the regulatory on/off switches on proteins. Its Smart Allostery platform combines AI-driven mining of large, diverse structural and biological data sets with a tailored pharmacology toolkit and bespoke medicinal chemistry to design first-in-class oral small molecules, and has been applied across E3 ligases, kinases and transcription factors. The company has raised roughly $190M across Series A, B and C financings and advanced its lead candidate HST-1011, an oral allosteric CBL-B inhibitor, into first-in-human dosing for cancer, alongside programs in autoimmune disease. HotSpot sells medicines and research collaborations, not software: it publishes no public developer program, API, SDK or machine-readable contract of any kind.

## Kin Score — 9.4 / 100 (minimal)

Scored 2026-08-25 under rubric 0.14.0. Trend: flat (+0.0 from 9.4).

| Facet | Score |
|---|---|
| Discoverability | 50.0 |
| Contract Quality | 0.0 |
| Governance | 0.0 |
| Contract Governance | 0.0 |
| Operational Transparency | 2.6 |
| Developer Ergonomics | 0.0 |
| Commercial Clarity | 21.1 |
| Access Clarity | 21.1 |

Regulatory layer — **Health**: 17.5 (matched via tags).

## Agent readiness — 0.0 (human-only)

| Dimension | Value |
|---|---|
| Spec Presence | no |
| Agentic Access | no |
| Reversibility Documented | no |
| MCP Server | no |
| Auth Clarity | no |
| Idempotency | no |
| Error Semantics | no |
| OpenAPI Examples | no |
| Rate Limit Signal | no |
| Event Surface Described | no |
| Agent Skills | no |
| Well Known Catalog | no |
| Consent Identity | no |
| Agent Card | no |
| Dry Run Mode | no |
| Delegated Identity | no |
| Protected Resource Metadata | no |
| Dynamic Client Registration | no |
| Agentic Commerce | no |

## Security (1)

- **Hotspot Therapeutics Domain Security** — TLSv1.3 · DMARC

## Tags

Company, Biotechnology, Pharmaceuticals, Drug Discovery, Life Sciences, Oncology, Immunology, Artificial Intelligence, Health

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Profiled by [API Evangelist](https://apievangelist.com) and published on [APIs.io](https://apis.io/providers/hotspot-therapeutics/). Scores are computed from the provider's own public artifacts under a published rubric.