# Engrail Therapeutics

**Canonical:** https://apis.io/providers/engrail-therapeutics/  
**Website:** https://www.engrail.com/  
**APIs profiled:** 2

Engrail Therapeutics is a clinical-stage precision-neuroscience pharmaceutical company founded in 2019 and headquartered in San Diego, California. It applies precision chemistry and pharmacology to scientifically validated mechanisms of action, developing targeted small-molecule therapies for neuropsychiatric and neurodevelopmental diseases with significant unmet need — including generalized anxiety disorder, major depressive disorder characterized by anhedonia, post-traumatic stress disorder and rare neurodegenerative conditions. Its lead program, ENX-102, is a highly selective GABA-A alpha-2,3,5 positive allosteric modulator in Phase 2 (the ENCALM trial) for generalized anxiety disorder; ENX-104 is in clinical development for anhedonic depression. The company closed an oversubscribed $157M Series B in March 2024 co-led by F-Prime Capital, Forbion and Norwest Venture Partners, bringing total capital raised since inception past $220M. Engrail publishes no product or developer API; the machine-readable surfaces catalogued here are the public read-only content API and the OAuth-protected Model Context Protocol servers exposed by its corporate website.

## Kin Score — 38.8 / 100 (thin)

Scored 2026-08-25 under rubric 0.14.0. Trend: flat (-0.8 from 39.6).

| Facet | Score |
|---|---|
| Discoverability | 79.6 |
| Contract Quality | 55.1 |
| Governance | 30.3 |
| Contract Governance | 30.3 |
| Operational Transparency | 0.0 |
| Developer Ergonomics | 20.8 |
| Commercial Clarity | 21.1 |
| Access Clarity | 21.1 |

Regulatory layer — **Health**: 52.5 (matched via tags).

## Agent readiness — 42.7 (agent-ready)

| Dimension | Value |
|---|---|
| Spec Presence | yes |
| Agentic Access | no |
| Reversibility Documented | na |
| MCP Server | verified |
| Auth Clarity | served |
| Idempotency | na |
| Error Semantics | no |
| OpenAPI Examples | no |
| Rate Limit Signal | no |
| Event Surface Described | no |
| Agent Skills | derived |
| Well Known Catalog | no |
| Consent Identity | no |
| Agent Card | no |
| Dry Run Mode | na |
| Delegated Identity | served |
| Protected Resource Metadata | verified |
| Dynamic Client Registration | no |
| Agentic Commerce | no |

## APIs (2)

- **Engrail Therapeutics Site Content API** — The public, anonymously-readable content API exposed by engrail.com at /wp-json/wp/v2. Sixteen read operations over posts, pages, media, categories, tags, comments, and the site...
- **Engrail Therapeutics MCP Servers** — Two live Model Context Protocol servers registered under the `mcp` REST namespace on engrail.com, fronted by RFC 8414 and RFC 9728 OAuth discovery documents at the apex. Both ar...

## MCP servers (1)

- **Engrail Therapeutics MCP Server**

## Security (2)

- **Engrail Therapeutics Authentication** — http/oauth2 · 2 schemes
- **Engrail Therapeutics Domain Security** — TLSv1.3 · HSTS · DMARC

## Tags

Company, Biotechnology, Pharmaceuticals, Life Sciences, Neuroscience, Clinical Trials, Drug Development, Healthcare, Mental Health, MCP

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Profiled by [API Evangelist](https://apievangelist.com) and published on [APIs.io](https://apis.io/providers/engrail-therapeutics/). Scores are computed from the provider's own public artifacts under a published rubric.