# Cullgen

**Canonical:** https://apis.io/providers/cullgen/  
**Website:** https://www.cullgen.com/  
**APIs profiled:** 0

Cullgen Inc. is a clinical-stage biopharmaceutical company headquartered in San Diego, California, founded in 2018 and focused on first-in-class targeted protein degradation medicines. Its proprietary uSMITE (ubiquitin-mediated, small molecule-induced target elimination) platform harnesses the body's own ubiquitin-proteasome system to selectively degrade disease-causing intracellular proteins, including targets considered undruggable by conventional small molecules, and the company extends that chemistry into degrader-antibody conjugates (DACs). Its lead TRK degrader program has entered Phase 1 clinical dosing, and the company has partnered with Astellas and taken investment from AstraZeneca. Gyre Therapeutics completed an all-stock acquisition of Cullgen valued at approximately $300 million on 4 May 2026. Cullgen publishes a corporate marketing website only: profiling on 2026-08-04 found no developer portal, documentation, machine-readable API contract, package registry presence, or public code repositories.

## Kin Score — 6.4 / 100 (minimal)

Scored 2026-08-17 under rubric 0.11.0. Trend: flat (+0.0 from 6.4).

| Facet | Score |
|---|---|
| Discoverability | 57.4 |
| Contract Quality | 0.0 |
| Governance | 0.0 |
| Operational Transparency | 0.0 |
| Developer Ergonomics | 2.2 |
| Commercial Clarity | 0.0 |

Regulatory layer — **Health**: 7.5 (matched via tags).

## Agent readiness — 0.0 (human-only)

| Dimension | Value |
|---|---|
| Spec Presence | no |
| Agentic Access | no |
| MCP Server | no |
| Auth Clarity | no |
| Idempotency | no |
| Error Semantics | no |
| OpenAPI Examples | no |
| Rate Limit Signal | no |
| Event Surface Described | no |
| Agent Skills | no |
| Well Known Catalog | no |
| Consent Identity | no |
| Agent Card | no |
| Dry Run Mode | no |

## Security (1)

- **Cullgen Domain Security** — TLSv1.3 · DMARC

## Tags

Company, Biotechnology, Pharmaceuticals, Life Sciences, Drug Discovery, Targeted Protein Degradation, Oncology, Clinical Stage

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Profiled by [API Evangelist](https://apievangelist.com) and published on [APIs.io](https://apis.io/providers/cullgen/). Scores are computed from the provider's own public artifacts under a published rubric.