# Combinatorx

**Canonical:** https://apis.io/providers/combinatorx/  
**APIs profiled:** 0

CombinatoRx, Inc. was a Cambridge/Boston, Massachusetts biopharmaceutical company (SEC CIK 0001135906, SIC 2834 Pharmaceutical Preparations, incorporated in Delaware) that pursued combination drug discovery — screening pairs of approved drugs for synergistic therapeutic effects. It registered with the SEC in 2002 and traded publicly following its 2005 IPO. The company was renamed Zalicus Inc. in September 2010 after its combination with Neuromed Pharmaceuticals, and renamed again to EPIRUS Biopharmaceuticals, Inc. in July 2014 after merging with EPIRUS. EPIRUS was delisted in September 2016 (Form 25-NSE) and its SEC registration was formally revoked on 2024-05-14. The company is defunct: it operated no developer program and published no public API, SDK, or developer documentation, and combinatorx.com is now a parked NameBright listing unrelated to the original company. This profile is retained as a historical record of a Canaan Partners portfolio company and has no API surface to catalog.

## Kin Score — 2.2 / 100 (minimal)

Scored 2026-08-20 under rubric 0.12.0. Trend: flat (+0.0 from 2.2).

| Facet | Score |
|---|---|
| Discoverability | 50.0 |
| Contract Quality | 0.0 |
| Governance | 0.0 |
| Contract Governance | 0.0 |
| Operational Transparency | 0.0 |
| Developer Ergonomics | 0.0 |
| Commercial Clarity | 0.0 |
| Access Clarity | 0.0 |

Regulatory layer — **Health**: 0.0 (matched via tags).

## Agent readiness — 0.0 (human-only)

| Dimension | Value |
|---|---|
| Spec Presence | no |
| Agentic Access | no |
| Reversibility Documented | no |
| MCP Server | no |
| Auth Clarity | no |
| Idempotency | no |
| Error Semantics | no |
| OpenAPI Examples | no |
| Rate Limit Signal | no |
| Event Surface Described | no |
| Agent Skills | no |
| Well Known Catalog | no |
| Consent Identity | no |
| Agent Card | no |
| Dry Run Mode | no |

## Access

Unknown — onboarding: unknown, pricing: unknown, trial: no (confidence: low).

## Tags

Company, Biotechnology, Pharmaceuticals, Drug Discovery, Life Sciences, Healthcare, Defunct, Venture Backed

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Profiled by [API Evangelist](https://apievangelist.com) and published on [APIs.io](https://apis.io/providers/combinatorx/). Scores are computed from the provider's own public artifacts under a published rubric.