# City Therapeutics

**Canonical:** https://apis.io/providers/city-therapeutics/  
**Website:** https://www.citytx.com/  
**APIs profiled:** 0

City Therapeutics, Inc. is a privately held, clinical-stage biotechnology company headquartered at 399 Binney Street in Kendall Square, Cambridge, Massachusetts, founded in 2024 by pioneers of RNA interference including John Maraganore, Phillip Zamore, Kotaro Nakanishi, Yukihide Tomari and Mark Keating. The company engineers next-generation RNAi trigger molecules — including its proprietary cleavage-inducing tiny (city) RNAs — and pairs them with precision targeting ligands designed to deliver siRNAs beyond the liver into ocular, CNS and other extrahepatic tissues. Its pipeline includes CITY-FXI, a Factor XI-targeting candidate for thromboembolic disease, and CITY-RBP4 for Stargardt disease and geographic atrophy, alongside undisclosed hepatic, ocular and CNS programs. City Therapeutics raised a $135M Series A in October 2024 and a $99.5M Series B in June 2026, and holds research collaborations with Biogen and Bausch + Lomb. City Therapeutics publishes no public developer program, API, or machine-readable interface; it is catalogued here as a company profile only.

## Kin Score — 10.3 / 100 (minimal)

Scored 2026-08-30 under rubric 0.17.2. Trend: flat (+0.0 from 10.3).

| Facet | Score |
|---|---|
| Discoverability | 57.4 |
| Contract Quality | 0.0 |
| Governance | 0.0 |
| Contract Governance | 0.0 |
| Operational Transparency | 0.0 |
| Developer Ergonomics | 2.4 |
| Commercial Clarity | 21.1 |
| Access Clarity | 21.1 |

Regulatory layer — **Health**: 17.5 (matched via tags).

## Agent readiness — 0.0 (human-only)

| Dimension | Value |
|---|---|
| Spec Presence | no |
| Agentic Access | no |
| Reversibility Documented | no |
| MCP Server | no |
| Auth Clarity | no |
| Idempotency | no |
| Error Semantics | no |
| OpenAPI Examples | no |
| Rate Limit Signal | no |
| Event Surface Described | no |
| Agent Skills | no |
| Well Known Catalog | no |
| Consent Identity | no |
| Agent Card | no |
| Dry Run Mode | no |
| Delegated Identity | no |
| Protected Resource Metadata | no |
| Dynamic Client Registration | no |
| Agentic Commerce | no |

## Security (1)

- **City Therapeutics Domain Security** — TLSv1.3 · HSTS · DMARC

## Tags

Company, Biotechnology, Pharmaceuticals, Life Sciences, Therapeutics, RNAi, Drug Discovery, Clinical Stage, Genetic Medicine

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Profiled by [API Evangelist](https://apievangelist.com) and published on [APIs.io](https://apis.io/providers/city-therapeutics/). Scores are computed from the provider's own public artifacts under a published rubric.