# Arc Institute

**Canonical:** https://apis.io/providers/arc-institute/  
**Website:** https://arcinstitute.org  
**APIs profiled:** 0

Arc Institute is an independent nonprofit biomedical research organization headquartered in Palo Alto, California, co-founded in 2021 by Silvana Konermann (Executive Director), Patrick Hsu (Core Investigator), and Stripe co-founder Patrick Collison. With 300+ staff ("Arconauts") across 9 core laboratories and 5 technology centers, Arc develops AI foundation models for biology that span DNA, RNA, proteins, and single cells. Its flagship releases include Evo (Science, 2024) and Evo 2 (Nature, 2026) — DNA foundation models trained on trillions of nucleotides at single-nucleotide resolution with up to a 1-megabase context; STATE and Stack single-cell foundation models for cellular perturbation and in-context learning; the Arc Virtual Cell Atlas; the SRAgent LLM agents for bioinformatics; and the BINSEQ binary sequencing format. Models are released under Apache 2.0 on GitHub and Hugging Face, with hosted inference for Evo 2 available through NVIDIA BioNeMo and the NVIDIA build.nvidia.com API. Arc is funded by philanthropic donations from Patrick and John Collison, Vitalik Buterin, the Ron Conway family, Dustin Moskovitz, Daniel Gross, Elad Gil, and other technology benefactors; it does not sell APIs, SaaS, or models commercially.

## Kin Score — 5.8 / 100 (minimal)

Scored 2026-08-20 under rubric 0.12.0. Trend: flat (+0.0 from 5.8).

| Facet | Score |
|---|---|
| Discoverability | 50.0 |
| Contract Quality | 0.0 |
| Governance | 0.0 |
| Contract Governance | 0.0 |
| Operational Transparency | 2.6 |
| Developer Ergonomics | 2.4 |
| Commercial Clarity | 0.0 |
| Access Clarity | 0.0 |

## Agent readiness — 0.0 (human-only)

| Dimension | Value |
|---|---|
| Spec Presence | no |
| Agentic Access | no |
| Reversibility Documented | no |
| MCP Server | no |
| Auth Clarity | no |
| Idempotency | no |
| Error Semantics | no |
| OpenAPI Examples | no |
| Rate Limit Signal | no |
| Event Surface Described | no |
| Agent Skills | no |
| Well Known Catalog | no |
| Consent Identity | no |
| Agent Card | no |
| Dry Run Mode | no |

## Access

Unknown — onboarding: unknown, pricing: unknown, trial: no (confidence: low).

## Security (1)

- **Arc Institute Domain Security** — TLSv1.3 · HSTS · DNSSEC · DMARC

## Tags

Biomedical Research, Computational Biology, Genomics, DNA Foundation Models, Foundation Models, Single Cell, Protein Engineering, Evo, Evo 2, Bioinformatics, Non-Profit, Open-Source, Machine-Learning, AI for Science

---

Profiled by [API Evangelist](https://apievangelist.com) and published on [APIs.io](https://apis.io/providers/arc-institute/). Scores are computed from the provider's own public artifacts under a published rubric.