# CIViC — Clinical Interpretation of Variants in Cancer

**Canonical:** https://apis.io/apis/washington-university-in-st-louis/civic/  
**Provider:** Washington University in St. Louis — https://apis.io/providers/washington-university-in-st-louis/  
**Base URL:** https://civicdb.org/api/graphql  
**Documentation:** https://civicdb.org/

CIViC — Clinical Interpretation of Variants in Cancer is one of 10 APIs that [Washington University in St. Louis](https://apis.io/providers/washington-university-in-st-louis/) publishes on the [APIs.io](https://apis.io/) network. Tagged areas include Genomics, Bioinformatics, Cancer, Knowledgebase, and GraphQL. The published artifact set on APIs.io includes API documentation, an API reference, authentication docs, and rate-limit docs.

A free, open, community-curated knowledgebase of the clinical significance of variants in cancer, built and operated by The McDonnell Genome Institute at Washington University School of Medicine and released under CC0 1.0. The public GraphQL API is the live contract: 502 named types, 112 root query fields covering molecular profiles, variants, features, evidence items, assertions, diseases, therapies, phenotypes, clinical trials, ACMG and ClinGen code vocabularies and data releases, and 47 mutations that expose the whole expert curation workflow — submit evidence, suggest and moderate revisions, approve assertions, and mint or revoke the caller's own API keys. Reads are anonymous; writes and higher rate ceilings take a free bearer-token key. The operator documents 3 requests/second over a five-minute window for anonymous callers and directs bulk consumers to CIViCpy. The former V1 REST API is documented as deprecated and no longer available. Operator is institution, not vendor: civicdb.org is an independent project domain, so the attribution rests on what the contract's own documentation says about itself, exactly as the ownership check requires.

## Machine-readable artifacts (8)

- **GraphQL** — https://raw.githubusercontent.com/api-evangelist/washington-university-in-st-louis/refs/heads/main/graphql/washington-university-in-st-louis-civic-schema.graphql
- **Documentation** — https://raw.githubusercontent.com/api-evangelist/washington-university-in-st-louis/refs/heads/main/graphql/washington-university-in-st-louis-civic.md
- **APIReference** — https://docs.civicdb.org/en/latest/api.html
- **Console** — https://civicdb.org/api/graphiql
- **Authentication** — https://raw.githubusercontent.com/api-evangelist/washington-university-in-st-louis/refs/heads/main/authentication/washington-university-in-st-louis-authentication.yml
- **RateLimits** — https://raw.githubusercontent.com/api-evangelist/washington-university-in-st-louis/refs/heads/main/rate-limits/washington-university-in-st-louis-rate-limits.yml
- **SourceCode** — https://github.com/griffithlab/civic-v2
- **APIsJSON** — https://raw.githubusercontent.com/api-evangelist/washington-university-in-st-louis/refs/heads/main/apis.yml

## Other Washington University in St. Louis APIs (9)

- [WashU Enterprise Integration APIs (MuleSoft Anypoint)](https://apis.io/apis/washington-university-in-st-louis/enterprise-apis/)
- [WashU Shibboleth Identity Provider (InCommon)](https://apis.io/apis/washington-university-in-st-louis/incommon-idp/)
- [WashU Scholarly Repository (OAI-PMH)](https://apis.io/apis/washington-university-in-st-louis/open-scholarship/)
- [Digital Commons Data@Becker (Research Data Repository)](https://apis.io/apis/washington-university-in-st-louis/digital-commons-data/)
- [DataCite Membership — Washington University in St. Louis Libraries](https://apis.io/apis/washington-university-in-st-louis/datacite/)
- [ROR Registration — Washington University in St. Louis](https://apis.io/apis/washington-university-in-st-louis/ror/)
- [WashU WordPress REST APIs (CampusPress)](https://apis.io/apis/washington-university-in-st-louis/wordpress-rest/)
- [CNDA — Central Neuroimaging Data Archive (XNAT)](https://apis.io/apis/washington-university-in-st-louis/cnda/)
- [BALSA Neuroimaging Database](https://apis.io/apis/washington-university-in-st-louis/balsa/)

## Tags

Genomics, Bioinformatics, Cancer, Knowledgebase, GraphQL, Research, Open Data, CC0

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Profiled by [API Evangelist](https://apievangelist.com) and published on [APIs.io](https://apis.io/apis/washington-university-in-st-louis/civic/). The API's provider profile, Kin Score and agent-readiness rating are at https://apis.io/providers/washington-university-in-st-louis/.