# UniProtKB REST API

**Canonical:** https://apis.io/apis/uniprot/uniprotkb-rest-api/  
**Provider:** UniProt — https://apis.io/providers/uniprot/  
**Base URL:** https://rest.uniprot.org/uniprotkb  
**Documentation:** https://www.uniprot.org/help/api

UniProtKB REST API is one of 7 APIs that [UniProt](https://apis.io/providers/uniprot/) publishes on the [APIs.io](https://apis.io/) network, described by a machine-readable OpenAPI specification. Tagged areas include Proteins, Sequences, Annotations, Swiss-Prot, and TrEMBL. The published artifact set on APIs.io includes API documentation and an OpenAPI specification.

Search and retrieve protein entries from UniProtKB, which integrates Swiss-Prot (manually reviewed) and TrEMBL (computationally annotated) databases. Supports full-text and field-specific queries, retrieval by accession, and streaming of large result sets. Returns rich protein records including sequences, functional annotations, cross-references, taxonomic lineage, subcellular location, disease associations, and literature citations.

## Machine-readable artifacts (4)

- **Documentation** — https://www.uniprot.org/help/api
- **OpenAPI** — https://www.uniprot.org/help/api
- **TermsOfService** — https://www.uniprot.org/help/license
- **APIsJSON** — https://raw.githubusercontent.com/api-evangelist/uniprot/refs/heads/main/apis.yml

## Other UniProt APIs (6)

- [UniRef REST API](https://apis.io/apis/uniprot/uniref-rest-api/)
- [UniParc REST API](https://apis.io/apis/uniprot/uniparc-rest-api/)
- [Proteomes REST API](https://apis.io/apis/uniprot/proteomes-rest-api/)
- [ID Mapping REST API](https://apis.io/apis/uniprot/id-mapping-rest-api/)
- [UniProt SPARQL Endpoint](https://apis.io/apis/uniprot/uniprot-sparql-endpoint/)
- [EBI Proteins REST API](https://apis.io/apis/uniprot/ebi-proteins-rest-api/)

## Tags

Proteins, Sequences, Annotations, Swiss-Prot, TrEMBL

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Profiled by [API Evangelist](https://apievangelist.com) and published on [APIs.io](https://apis.io/apis/uniprot/uniprotkb-rest-api/). The API's provider profile, Kin Score and agent-readiness rating are at https://apis.io/providers/uniprot/.