# Surescripts E-Prescribing

**Canonical:** https://apis.io/apis/surescripts/surescripts-e-prescribing-api/  
**Provider:** Surescripts — https://apis.io/providers/surescripts/  
**Documentation:** https://docs.surescripts.com/eprescribing/home

Surescripts E-Prescribing is one of 8 APIs that [Surescripts](https://apis.io/providers/surescripts/) publishes on the [APIs.io](https://apis.io/) network. Tagged areas include e-Prescribing, NCPDP SCRIPT, NewRx, and CancelRx. The published artifact set on APIs.io includes API documentation and an API reference.

Routes electronic prescriptions between prescribers and pharmacies over the NCPDP SCRIPT standard (version 2023011), supporting NewRx, RxRenewalRequest/Response, RxChangeRequest/Response, RxTransfer, RxFill, CancelRx, and Status/Error/Verify transactions, plus Electronic Prescribing for Controlled Substances (EPCS). Delivered via certified EHR and pharmacy system integrations, not a public REST endpoint - the transaction set is documented in the E-Prescribing Companion Guide on the Surescripts Developer Portal.

## Machine-readable artifacts (2)

- **Documentation** — https://docs.surescripts.com/eprescribing/home
- **APIReference** — https://docs.surescripts.com/eprescribing/guide

## Other Surescripts APIs (7)

- [Surescripts Medication History for Populations FHIR API](https://apis.io/apis/surescripts/surescripts-medication-history-populations-fhir-api/)
- [Surescripts Formulary Download API](https://apis.io/apis/surescripts/surescripts-formulary-download-api/)
- [Surescripts Eligibility and Formulary](https://apis.io/apis/surescripts/surescripts-eligibility-formulary-api/)
- [Surescripts Real-Time Prescription Benefit](https://apis.io/apis/surescripts/surescripts-real-time-prescription-benefit-api/)
- [Surescripts Electronic Prior Authorization](https://apis.io/apis/surescripts/surescripts-electronic-prior-authorization-api/)
- [Surescripts Clinical Direct Messaging](https://apis.io/apis/surescripts/surescripts-clinical-direct-messaging-api/)
- [Surescripts Record Locator and Exchange](https://apis.io/apis/surescripts/surescripts-record-locator-exchange-api/)

## Tags

e-Prescribing, NCPDP SCRIPT, NewRx, CancelRx

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Profiled by [API Evangelist](https://apievangelist.com) and published on [APIs.io](https://apis.io/apis/surescripts/surescripts-e-prescribing-api/). The API's provider profile, Kin Score and agent-readiness rating are at https://apis.io/providers/surescripts/.