# Sigma-Aldrich Chemical Structure Search API

**Canonical:** https://apis.io/apis/sigma-aldrich/sigma-aldrich-structure-search-api/  
**Provider:** Sigma-Aldrich — https://apis.io/providers/sigma-aldrich/  
**Documentation:** https://www.sigmaaldrich.com/US/en/support/contact-us

Sigma-Aldrich Chemical Structure Search API is one of 6 APIs that [Sigma-Aldrich](https://apis.io/providers/sigma-aldrich/) publishes on the [APIs.io](https://apis.io/) network. Tagged areas include Chemistry, Cheminformatics, Structure Search, and SMILES. The published artifact set on APIs.io includes API documentation.

The Sigma-Aldrich Chemical Structure Search API enables substructure, exact structure, and similarity searches against the Sigma-Aldrich chemical catalog using SMILES, InChI, or molecular formula notation. Supports configuring similarity thresholds and returning ranked results for drug discovery, materials research, and synthetic chemistry workflows.

## Machine-readable artifacts (2)

- **Documentation** — https://www.sigmaaldrich.com/US/en/support/contact-us
- **APIsJSON** — https://raw.githubusercontent.com/api-evangelist/sigma-aldrich/refs/heads/main/apis.yml

## Other Sigma-Aldrich APIs (5)

- [Sigma-Aldrich Safety Data Sheet API](https://apis.io/apis/sigma-aldrich/sigma-aldrich-sds-api/)
- [Sigma-Aldrich Pricing and Availability API](https://apis.io/apis/sigma-aldrich/sigma-aldrich-pricing-and-availability-api/)
- [Sigma-Aldrich Products API](https://apis.io/apis/sigma-aldrich/sigma-aldrich-products-api/)
- [Sigma-Aldrich Safety Data Sheets API](https://apis.io/apis/sigma-aldrich/sigma-aldrich-safety-data-sheets-api/)
- [Sigma-Aldrich Structures API](https://apis.io/apis/sigma-aldrich/sigma-aldrich-structures-api/)

## Tags

Chemistry, Cheminformatics, Structure Search, SMILES

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Profiled by [API Evangelist](https://apievangelist.com) and published on [APIs.io](https://apis.io/apis/sigma-aldrich/sigma-aldrich-structure-search-api/). The API's provider profile, Kin Score and agent-readiness rating are at https://apis.io/providers/sigma-aldrich/.