# Onepot API

**Canonical:** https://apis.io/apis/onepot/onepot-api/  
**Provider:** Onepot — https://apis.io/providers/onepot/  
**Base URL:** https://www.onepot.ai  
**Documentation:** https://www.onepot.ai/api

Onepot API is published by [Onepot](https://apis.io/providers/onepot/) on the [APIs.io](https://apis.io/) network. Tagged areas include Chemistry, Cheminformatics, Molecule Search, Retrosynthesis, and Synthesis. The published artifact set on APIs.io includes API documentation and a getting-started guide.

Programmatic access to onepot CORE for make-on-demand molecule discovery and synthesis. Run similarity (Tanimoto) and substructure (SMILES/SMARTS) search, optional retrosynthetic decomposition with building-block/price/risk filters, stream progress and results over server-sent events, and place synthesis orders. Accessed via the first-party Python client (pip install onepot) using an API key; access is gated ("Request API access").

## Machine-readable artifacts (3)

- **Documentation** — https://www.onepot.ai/api
- **GettingStarted** — https://www.onepot.ai/api
- **APIsJSON** — https://raw.githubusercontent.com/api-evangelist/onepot/refs/heads/main/apis.yml

## Tags

Chemistry, Cheminformatics, Molecule Search, Retrosynthesis, Synthesis

---

Profiled by [API Evangelist](https://apievangelist.com) and published on [APIs.io](https://apis.io/apis/onepot/onepot-api/). The API's provider profile, Kin Score and agent-readiness rating are at https://apis.io/providers/onepot/.