# PubChem PUG REST API

**Canonical:** https://apis.io/apis/ncbi/pubchem-pug-rest-api/  
**Provider:** National Center for Biotechnology Information (NCBI) — https://apis.io/providers/ncbi/  
**Base URL:** https://pubchem.ncbi.nlm.nih.gov/rest/pug  
**Documentation:** https://pubchem.ncbi.nlm.nih.gov/docs/pug-rest

PubChem PUG REST API is one of 14 APIs that [National Center for Biotechnology Information (NCBI)](https://apis.io/providers/ncbi/) publishes on the [APIs.io](https://apis.io/) network. Tagged areas include Chemistry, Compounds, PubChem, Structures, and Bioassay. The published artifact set on APIs.io includes API documentation and rate-limit docs.

The PubChem Power User Gateway (PUG) REST API provides programmatic access to PubChem's chemical compound, substance, and bioassay data. Developers can retrieve compound properties, structures, synonyms, and cross-references by name, SMILES, InChI, CID, SID, or AID. The API supports structure search operations and integrates with E-utilities for cross-database queries. Responses are available in JSON, XML, SDF, and other formats.

## Machine-readable artifacts (3)

- **Documentation** — https://pubchem.ncbi.nlm.nih.gov/docs/pug-rest
- **RateLimits** — https://kinlane.github.io/ncbi/rate-limits/pubchem-pug-rest.yml
- **Plans** — https://kinlane.github.io/ncbi/plans/pubchem-pug-rest.yml

## Other National Center for Biotechnology Information (NCBI) APIs (12)

- [NCBI Entrez E-utilities API](https://apis.io/apis/ncbi/ncbi-entrez-e-utilities-api/)
- [NCBI BLAST URL API](https://apis.io/apis/ncbi/ncbi-blast-url-api/)
- [PMC Open Access API (OA Service)](https://apis.io/apis/ncbi/pmc-open-access-api-oa-service/)
- [PMC ID Converter API](https://apis.io/apis/ncbi/pmc-id-converter-api/)
- [PMC OAI-PMH Service](https://apis.io/apis/ncbi/pmc-oai-pmh-service/)
- [National Center for Biotechnology Information (NCBI) BioSample API](https://apis.io/apis/ncbi/ncbi-biosample-api/)
- [National Center for Biotechnology Information (NCBI) Gene API](https://apis.io/apis/ncbi/ncbi-gene-api/)
- [National Center for Biotechnology Information (NCBI) Genome API](https://apis.io/apis/ncbi/ncbi-genome-api/)
- [National Center for Biotechnology Information (NCBI) Organelle API](https://apis.io/apis/ncbi/ncbi-organelle-api/)
- [National Center for Biotechnology Information (NCBI) Prokaryote API](https://apis.io/apis/ncbi/ncbi-prokaryote-api/)
- [National Center for Biotechnology Information (NCBI) Taxonomy API](https://apis.io/apis/ncbi/ncbi-taxonomy-api/)
- [National Center for Biotechnology Information (NCBI) Version API](https://apis.io/apis/ncbi/ncbi-version-api/)

## Tags

Chemistry, Compounds, PubChem, Structures, Bioassay

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Profiled by [API Evangelist](https://apievangelist.com) and published on [APIs.io](https://apis.io/apis/ncbi/pubchem-pug-rest-api/). The API's provider profile, Kin Score and agent-readiness rating are at https://apis.io/providers/ncbi/.