# EvolutionaryScale ESM Python SDK

**Canonical:** https://apis.io/apis/evolutionaryscale/esm-python-sdk/  
**Provider:** EvolutionaryScale — https://apis.io/providers/evolutionaryscale/  
**Documentation:** https://github.com/Biohub/esm

EvolutionaryScale ESM Python SDK is one of 7 APIs that [EvolutionaryScale](https://apis.io/providers/evolutionaryscale/) publishes on the [APIs.io](https://apis.io/) network. Tagged areas include Artificial Intelligence, Biology, SDK, Python, and Open-Source. The published artifact set on APIs.io includes API documentation and code examples.

Official Python SDK packaging ESM3 and ESM Cambrian model loaders, the `ESMProtein` multi-track data model, generation/sampling configurations, structure tokenization utilities, and a `forge.client()` factory that swaps local checkpoints for Forge-hosted inference without code changes. Installable from PyPI as `esm`. Mixed commercial / non-commercial licenses.

## Machine-readable artifacts (7)

- **SourceCode** — https://github.com/Biohub/esm
- **SDKs** — https://pypi.org/project/esm/
- **Documentation** — https://huggingface.co/biohub/esm3-sm-open-v1
- **Documentation** — https://huggingface.co/biohub/esmc-300m-2024-12
- **Documentation** — https://huggingface.co/biohub/esmc-600m-2024-12
- **CodeExamples** — https://github.com/Biohub/esm/tree/main/cookbook
- **APIsJSON** — https://raw.githubusercontent.com/api-evangelist/evolutionaryscale/refs/heads/main/apis.yml

## Other EvolutionaryScale APIs (6)

- [EvolutionaryScale Embeddings API](https://apis.io/apis/evolutionaryscale/evolutionaryscale-embeddings-api/)
- [EvolutionaryScale Encoding API](https://apis.io/apis/evolutionaryscale/evolutionaryscale-encoding-api/)
- [EvolutionaryScale Generation API](https://apis.io/apis/evolutionaryscale/evolutionaryscale-generation-api/)
- [EvolutionaryScale MSA API](https://apis.io/apis/evolutionaryscale/evolutionaryscale-msa-api/)
- [EvolutionaryScale Sampling API](https://apis.io/apis/evolutionaryscale/evolutionaryscale-sampling-api/)
- [EvolutionaryScale Structure API](https://apis.io/apis/evolutionaryscale/evolutionaryscale-structure-api/)

## Tags

Artificial Intelligence, Biology, SDK, Python, Open-Source, ESM3, ESM Cambrian

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Profiled by [API Evangelist](https://apievangelist.com) and published on [APIs.io](https://apis.io/apis/evolutionaryscale/esm-python-sdk/). The API's provider profile, Kin Score and agent-readiness rating are at https://apis.io/providers/evolutionaryscale/.