# Ensembl REST API

**Canonical:** https://apis.io/apis/ensembl/rest-api/  
**Provider:** Ensembl — https://apis.io/providers/ensembl/  
**Base URL:** https://rest.ensembl.org  
**Documentation:** https://rest.ensembl.org

Ensembl REST API is published by [Ensembl](https://apis.io/providers/ensembl/) on the [APIs.io](https://apis.io/) network. Tagged areas include Genomics, Gene Annotation, Variant Effect Prediction, Comparative Genomics, and Sequence Retrieval. The published artifact set on APIs.io includes API documentation, a changelog, rate-limit docs, a GitHub repository, and a JSON-LD context.

The Ensembl REST API (v15.12) provides language-agnostic HTTP access to genome annotation data across hundreds of vertebrate and eukaryotic species. It exposes 19 endpoint categories covering genome sequences, gene and transcript lookups, variant effect prediction (VEP), comparative genomics (gene trees, homology, alignments), coordinate mapping between assemblies, regulatory features, linkage disequilibrium, ontology and taxonomy queries, phenotype annotations, and GA4GH-compliant genomic data access. Both GET and POST methods are available; POST endpoints support batch operations for multiple identifiers. No authentication is required for public use.

## Machine-readable artifacts (7)

- **Documentation** — https://rest.ensembl.org/documentation
- **Website** — https://rest.ensembl.org
- **ChangeLog** — https://github.com/Ensembl/ensembl-rest/wiki/Change-Log
- **RateLimits** — https://github.com/Ensembl/ensembl-rest/wiki/Rate-Limits
- **GitHubRepository** — https://github.com/Ensembl/ensembl-rest
- **JSONLD** — https://raw.githubusercontent.com/api-evangelist/ensembl/refs/heads/main/json-ld/ensembl-rest-api.json
- **APIsJSON** — https://raw.githubusercontent.com/api-evangelist/ensembl/refs/heads/main/apis.yml

## Tags

Genomics, Gene Annotation, Variant Effect Prediction, Comparative Genomics, Sequence Retrieval, VEP, GA4GH

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Profiled by [API Evangelist](https://apievangelist.com) and published on [APIs.io](https://apis.io/apis/ensembl/rest-api/). The API's provider profile, Kin Score and agent-readiness rating are at https://apis.io/providers/ensembl/.